High-avidity IgA protects the intestine by enchaining growing bacteria.
Identifieur interne : 000A83 ( Main/Exploration ); précédent : 000A82; suivant : 000A84High-avidity IgA protects the intestine by enchaining growing bacteria.
Auteurs : Kathrin Moor [Suisse] ; Médéric Diard [Suisse] ; Mikael E. Sellin [Suisse] ; Boas Felmy [Suisse] ; Sandra Y. Wotzka [Suisse] ; Albulena Toska [Suisse] ; Erik Bakkeren [Suisse] ; Markus Arnoldini [Suisse] ; Florence Bansept [France] ; Alma Dal Co [Suisse] ; Tom Völler [Suisse] ; Andrea Minola [Suisse] ; Blanca Fernandez-Rodriguez [Suisse] ; Gloria Agatic [Suisse] ; Sonia Barbieri [Suisse] ; Luca Piccoli [Suisse] ; Costanza Casiraghi [Suisse] ; Davide Corti [Suisse] ; Antonio Lanzavecchia [Suisse] ; Roland R. Regoes [Suisse] ; Claude Loverdo [France] ; Roman Stocker [Suisse] ; Douglas R. Brumley [Suisse] ; Wolf-Dietrich Hardt [Suisse] ; Emma Slack [Suisse]Source :
- Nature [ 1476-4687 ] ; 2017.
Descripteurs français
- KwdFr :
- Adhérence bactérienne, Affinité des anticorps, Animaux, Caecum (immunologie), Caecum (microbiologie), Conjugaison génétique, Femelle, Humains, Immunoglobuline A (immunologie), Intestins (immunologie), Intestins (microbiologie), Mâle, Numération de colonies microbiennes, Plasmides (génétique), Salmonella typhimurium (croissance et développement), Salmonella typhimurium (génétique), Salmonella typhimurium (immunologie), Salmonella typhimurium (pathogénicité), Salmonelloses (), Salmonelloses (immunologie), Salmonelloses (microbiologie), Souris, Vaccins antibactériens.
- MESH :
- croissance et développement : Salmonella typhimurium.
- génétique : Plasmides, Salmonella typhimurium.
- immunologie : Caecum, Immunoglobuline A, Intestins, Salmonella typhimurium, Salmonelloses.
- microbiologie : Caecum, Intestins, Salmonelloses.
- pathogénicité : Salmonella typhimurium.
- Adhérence bactérienne, Affinité des anticorps, Animaux, Conjugaison génétique, Femelle, Humains, Mâle, Numération de colonies microbiennes, Salmonelloses, Souris, Vaccins antibactériens.
English descriptors
- KwdEn :
- Animals, Antibody Affinity, Bacterial Adhesion, Bacterial Vaccines, Cecum (immunology), Cecum (microbiology), Colony Count, Microbial, Conjugation, Genetic, Female, Humans, Immunoglobulin A (immunology), Intestines (immunology), Intestines (microbiology), Male, Mice, Plasmids (genetics), Salmonella Infections (immunology), Salmonella Infections (microbiology), Salmonella Infections (prevention & control), Salmonella typhimurium (genetics), Salmonella typhimurium (growth & development), Salmonella typhimurium (immunology), Salmonella typhimurium (pathogenicity).
- MESH :
- chemical , immunology : Immunoglobulin A.
- chemical : Bacterial Vaccines.
- genetics : Plasmids, Salmonella typhimurium.
- growth & development : Salmonella typhimurium.
- immunology : Cecum, Intestines, Salmonella Infections, Salmonella typhimurium.
- microbiology : Cecum, Intestines, Salmonella Infections.
- pathogenicity : Salmonella typhimurium.
- prevention & control : Salmonella Infections.
- Animals, Antibody Affinity, Bacterial Adhesion, Colony Count, Microbial, Conjugation, Genetic, Female, Humans, Male, Mice.
Abstract
Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly neutralizing virulence factors or by poorly defined mechanisms that physically impede bacterial interactions with the gut tissues ('immune exclusion'). IgA-mediated cross-linking clumps bacteria in the gut lumen and is critical for protection against infection by non-typhoidal Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium). However, classical agglutination, which was thought to drive this process, is efficient only at high pathogen densities (≥10(8) non-motile bacteria per gram). In typical infections, much lower densities (10(0)-10(7) colony-forming units per gram) of rapidly dividing bacteria are present in the gut lumen. Here we show that a different physical process drives formation of clumps in vivo: IgA-mediated cross-linking enchains daughter cells, preventing their separation after division, and clumping is therefore dependent on growth. Enchained growth is effective at all realistic pathogen densities, and accelerates pathogen clearance from the gut lumen. Furthermore, IgA enchains plasmid-donor and -recipient clones into separate clumps, impeding conjugative plasmid transfer in vivo. Enchained growth is therefore a mechanism by which IgA can disarm and clear potentially invasive species from the intestinal lumen without requiring high pathogen densities, inflammation or bacterial killing. Furthermore, our results reveal an untapped potential for oral vaccines in combating the spread of antimicrobial resistance.
DOI: 10.1038/nature22058
PubMed: 28405025
Affiliations:
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Le document en format XML
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Regoes</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Integrative Biology, ETH Zürich, 8092 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Integrative Biology, ETH Zürich, 8092 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Loverdo, Claude" sort="Loverdo, Claude" uniqKey="Loverdo C" first="Claude" last="Loverdo">Claude Loverdo</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC, 75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Stocker, Roman" sort="Stocker, Roman" uniqKey="Stocker R" first="Roman" last="Stocker">Roman Stocker</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Brumley, Douglas R" sort="Brumley, Douglas R" uniqKey="Brumley D" first="Douglas R" last="Brumley">Douglas R. Brumley</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Hardt, Wolf Dietrich" sort="Hardt, Wolf Dietrich" uniqKey="Hardt W" first="Wolf-Dietrich" last="Hardt">Wolf-Dietrich Hardt</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Slack, Emma" sort="Slack, Emma" uniqKey="Slack E" first="Emma" last="Slack">Emma Slack</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28405025</idno><idno type="pmid">28405025</idno><idno type="doi">10.1038/nature22058</idno><idno type="wicri:Area/PubMed/Corpus">000E39</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E39</idno><idno type="wicri:Area/PubMed/Curation">000E36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E36</idno><idno type="wicri:Area/PubMed/Checkpoint">000E36</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E36</idno><idno type="wicri:Area/Ncbi/Merge">004630</idno><idno type="wicri:Area/Ncbi/Curation">004630</idno><idno type="wicri:Area/Ncbi/Checkpoint">004630</idno><idno type="wicri:Area/Main/Merge">000A78</idno><idno type="wicri:Area/Main/Curation">000A83</idno><idno type="wicri:Area/Main/Exploration">000A83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High-avidity IgA protects the intestine by enchaining growing bacteria.</title><author><name sortKey="Moor, Kathrin" sort="Moor, Kathrin" uniqKey="Moor K" first="Kathrin" last="Moor">Kathrin Moor</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Diard, Mederic" sort="Diard, Mederic" uniqKey="Diard M" first="Médéric" last="Diard">Médéric Diard</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Sellin, Mikael E" sort="Sellin, Mikael E" uniqKey="Sellin M" first="Mikael E" last="Sellin">Mikael E. Sellin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Felmy, Boas" sort="Felmy, Boas" uniqKey="Felmy B" first="Boas" last="Felmy">Boas Felmy</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Wotzka, Sandra Y" sort="Wotzka, Sandra Y" uniqKey="Wotzka S" first="Sandra Y" last="Wotzka">Sandra Y. Wotzka</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Toska, Albulena" sort="Toska, Albulena" uniqKey="Toska A" first="Albulena" last="Toska">Albulena Toska</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Bakkeren, Erik" sort="Bakkeren, Erik" uniqKey="Bakkeren E" first="Erik" last="Bakkeren">Erik Bakkeren</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Arnoldini, Markus" sort="Arnoldini, Markus" uniqKey="Arnoldini M" first="Markus" last="Arnoldini">Markus Arnoldini</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Bansept, Florence" sort="Bansept, Florence" uniqKey="Bansept F" first="Florence" last="Bansept">Florence Bansept</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC, 75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Co, Alma Dal" sort="Co, Alma Dal" uniqKey="Co A" first="Alma Dal" last="Co">Alma Dal Co</name><affiliation wicri:level="3"><nlm:affiliation>Department of Environmental Systems Science, ETH Zurich, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Environmental Systems Science, ETH Zurich, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Voller, Tom" sort="Voller, Tom" uniqKey="Voller T" first="Tom" last="Völler">Tom Völler</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Minola, Andrea" sort="Minola, Andrea" uniqKey="Minola A" first="Andrea" last="Minola">Andrea Minola</name><affiliation wicri:level="1"><nlm:affiliation>Humabs BioMed SA, 6500 Bellinzona, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Humabs BioMed SA, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Rodriguez, Blanca" sort="Fernandez Rodriguez, Blanca" uniqKey="Fernandez Rodriguez B" first="Blanca" last="Fernandez-Rodriguez">Blanca Fernandez-Rodriguez</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500</wicri:regionArea><wicri:noRegion>Bellinzona 6500</wicri:noRegion></affiliation></author><author><name sortKey="Agatic, Gloria" sort="Agatic, Gloria" uniqKey="Agatic G" first="Gloria" last="Agatic">Gloria Agatic</name><affiliation wicri:level="1"><nlm:affiliation>Humabs BioMed SA, 6500 Bellinzona, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Humabs BioMed SA, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Barbieri, Sonia" sort="Barbieri, Sonia" uniqKey="Barbieri S" first="Sonia" last="Barbieri">Sonia Barbieri</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500</wicri:regionArea><wicri:noRegion>Bellinzona 6500</wicri:noRegion></affiliation></author><author><name sortKey="Piccoli, Luca" sort="Piccoli, Luca" uniqKey="Piccoli L" first="Luca" last="Piccoli">Luca Piccoli</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500</wicri:regionArea><wicri:noRegion>Bellinzona 6500</wicri:noRegion></affiliation></author><author><name sortKey="Casiraghi, Costanza" sort="Casiraghi, Costanza" uniqKey="Casiraghi C" first="Costanza" last="Casiraghi">Costanza Casiraghi</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500</wicri:regionArea><wicri:noRegion>Bellinzona 6500</wicri:noRegion></affiliation></author><author><name sortKey="Corti, Davide" sort="Corti, Davide" uniqKey="Corti D" first="Davide" last="Corti">Davide Corti</name><affiliation wicri:level="1"><nlm:affiliation>Humabs BioMed SA, 6500 Bellinzona, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Humabs BioMed SA, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Regoes, Roland R" sort="Regoes, Roland R" uniqKey="Regoes R" first="Roland R" last="Regoes">Roland R. Regoes</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Integrative Biology, ETH Zürich, 8092 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Integrative Biology, ETH Zürich, 8092 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Loverdo, Claude" sort="Loverdo, Claude" uniqKey="Loverdo C" first="Claude" last="Loverdo">Claude Loverdo</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC, 75005 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC, 75005 Paris</wicri:regionArea><wicri:noRegion>75005 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Stocker, Roman" sort="Stocker, Roman" uniqKey="Stocker R" first="Roman" last="Stocker">Roman Stocker</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Brumley, Douglas R" sort="Brumley, Douglas R" uniqKey="Brumley D" first="Douglas R" last="Brumley">Douglas R. Brumley</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Hardt, Wolf Dietrich" sort="Hardt, Wolf Dietrich" uniqKey="Hardt W" first="Wolf-Dietrich" last="Hardt">Wolf-Dietrich Hardt</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Slack, Emma" sort="Slack, Emma" uniqKey="Slack E" first="Emma" last="Slack">Emma Slack</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Microbiology, ETH Zürich, 8093 Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author></analytic><series><title level="j">Nature</title><idno type="eISSN">1476-4687</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibody Affinity</term><term>Bacterial Adhesion</term><term>Bacterial Vaccines</term><term>Cecum (immunology)</term><term>Cecum (microbiology)</term><term>Colony Count, Microbial</term><term>Conjugation, Genetic</term><term>Female</term><term>Humans</term><term>Immunoglobulin A (immunology)</term><term>Intestines (immunology)</term><term>Intestines (microbiology)</term><term>Male</term><term>Mice</term><term>Plasmids (genetics)</term><term>Salmonella Infections (immunology)</term><term>Salmonella Infections (microbiology)</term><term>Salmonella Infections (prevention & control)</term><term>Salmonella typhimurium (genetics)</term><term>Salmonella typhimurium (growth & development)</term><term>Salmonella typhimurium (immunology)</term><term>Salmonella typhimurium (pathogenicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adhérence bactérienne</term><term>Affinité des anticorps</term><term>Animaux</term><term>Caecum (immunologie)</term><term>Caecum (microbiologie)</term><term>Conjugaison génétique</term><term>Femelle</term><term>Humains</term><term>Immunoglobuline A (immunologie)</term><term>Intestins (immunologie)</term><term>Intestins (microbiologie)</term><term>Mâle</term><term>Numération de colonies microbiennes</term><term>Plasmides (génétique)</term><term>Salmonella typhimurium (croissance et développement)</term><term>Salmonella typhimurium (génétique)</term><term>Salmonella typhimurium (immunologie)</term><term>Salmonella typhimurium (pathogénicité)</term><term>Salmonelloses ()</term><term>Salmonelloses (immunologie)</term><term>Salmonelloses (microbiologie)</term><term>Souris</term><term>Vaccins antibactériens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulin A</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Bacterial Vaccines</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plasmids</term><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Plasmides</term><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Caecum</term><term>Immunoglobuline A</term><term>Intestins</term><term>Salmonella typhimurium</term><term>Salmonelloses</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cecum</term><term>Intestines</term><term>Salmonella Infections</term><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Caecum</term><term>Intestins</term><term>Salmonelloses</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cecum</term><term>Intestines</term><term>Salmonella Infections</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Salmonella typhimurium</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Salmonella Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Affinity</term><term>Bacterial Adhesion</term><term>Colony Count, Microbial</term><term>Conjugation, Genetic</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adhérence bactérienne</term><term>Affinité des anticorps</term><term>Animaux</term><term>Conjugaison génétique</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Numération de colonies microbiennes</term><term>Salmonelloses</term><term>Souris</term><term>Vaccins antibactériens</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly neutralizing virulence factors or by poorly defined mechanisms that physically impede bacterial interactions with the gut tissues ('immune exclusion'). IgA-mediated cross-linking clumps bacteria in the gut lumen and is critical for protection against infection by non-typhoidal Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium). However, classical agglutination, which was thought to drive this process, is efficient only at high pathogen densities (≥10(8) non-motile bacteria per gram). In typical infections, much lower densities (10(0)-10(7) colony-forming units per gram) of rapidly dividing bacteria are present in the gut lumen. Here we show that a different physical process drives formation of clumps in vivo: IgA-mediated cross-linking enchains daughter cells, preventing their separation after division, and clumping is therefore dependent on growth. Enchained growth is effective at all realistic pathogen densities, and accelerates pathogen clearance from the gut lumen. Furthermore, IgA enchains plasmid-donor and -recipient clones into separate clumps, impeding conjugative plasmid transfer in vivo. Enchained growth is therefore a mechanism by which IgA can disarm and clear potentially invasive species from the intestinal lumen without requiring high pathogen densities, inflammation or bacterial killing. Furthermore, our results reveal an untapped potential for oral vaccines in combating the spread of antimicrobial resistance.</div></front></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country><region><li>Canton de Zurich</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Zurich</li></settlement></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Moor, Kathrin" sort="Moor, Kathrin" uniqKey="Moor K" first="Kathrin" last="Moor">Kathrin Moor</name></region><name sortKey="Agatic, Gloria" sort="Agatic, Gloria" uniqKey="Agatic G" first="Gloria" last="Agatic">Gloria Agatic</name><name sortKey="Arnoldini, Markus" sort="Arnoldini, Markus" uniqKey="Arnoldini M" first="Markus" last="Arnoldini">Markus Arnoldini</name><name sortKey="Bakkeren, Erik" sort="Bakkeren, Erik" uniqKey="Bakkeren E" first="Erik" last="Bakkeren">Erik Bakkeren</name><name sortKey="Barbieri, Sonia" sort="Barbieri, Sonia" uniqKey="Barbieri S" first="Sonia" last="Barbieri">Sonia Barbieri</name><name sortKey="Brumley, Douglas R" sort="Brumley, Douglas R" uniqKey="Brumley D" first="Douglas R" last="Brumley">Douglas R. Brumley</name><name sortKey="Casiraghi, Costanza" sort="Casiraghi, Costanza" uniqKey="Casiraghi C" first="Costanza" last="Casiraghi">Costanza Casiraghi</name><name sortKey="Co, Alma Dal" sort="Co, Alma Dal" uniqKey="Co A" first="Alma Dal" last="Co">Alma Dal Co</name><name sortKey="Corti, Davide" sort="Corti, Davide" uniqKey="Corti D" first="Davide" last="Corti">Davide Corti</name><name sortKey="Diard, Mederic" sort="Diard, Mederic" uniqKey="Diard M" first="Médéric" last="Diard">Médéric Diard</name><name sortKey="Felmy, Boas" sort="Felmy, Boas" uniqKey="Felmy B" first="Boas" last="Felmy">Boas Felmy</name><name sortKey="Fernandez Rodriguez, Blanca" sort="Fernandez Rodriguez, Blanca" uniqKey="Fernandez Rodriguez B" first="Blanca" last="Fernandez-Rodriguez">Blanca Fernandez-Rodriguez</name><name sortKey="Hardt, Wolf Dietrich" sort="Hardt, Wolf Dietrich" uniqKey="Hardt W" first="Wolf-Dietrich" last="Hardt">Wolf-Dietrich Hardt</name><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><name sortKey="Minola, Andrea" sort="Minola, Andrea" uniqKey="Minola A" first="Andrea" last="Minola">Andrea Minola</name><name sortKey="Piccoli, Luca" sort="Piccoli, Luca" uniqKey="Piccoli L" first="Luca" last="Piccoli">Luca Piccoli</name><name sortKey="Regoes, Roland R" sort="Regoes, Roland R" uniqKey="Regoes R" first="Roland R" last="Regoes">Roland R. Regoes</name><name sortKey="Sellin, Mikael E" sort="Sellin, Mikael E" uniqKey="Sellin M" first="Mikael E" last="Sellin">Mikael E. Sellin</name><name sortKey="Slack, Emma" sort="Slack, Emma" uniqKey="Slack E" first="Emma" last="Slack">Emma Slack</name><name sortKey="Stocker, Roman" sort="Stocker, Roman" uniqKey="Stocker R" first="Roman" last="Stocker">Roman Stocker</name><name sortKey="Toska, Albulena" sort="Toska, Albulena" uniqKey="Toska A" first="Albulena" last="Toska">Albulena Toska</name><name sortKey="Voller, Tom" sort="Voller, Tom" uniqKey="Voller T" first="Tom" last="Völler">Tom Völler</name><name sortKey="Wotzka, Sandra Y" sort="Wotzka, Sandra Y" uniqKey="Wotzka S" first="Sandra Y" last="Wotzka">Sandra Y. Wotzka</name></country><country name="France"><region name="Île-de-France"><name sortKey="Bansept, Florence" sort="Bansept, Florence" uniqKey="Bansept F" first="Florence" last="Bansept">Florence Bansept</name></region><name sortKey="Loverdo, Claude" sort="Loverdo, Claude" uniqKey="Loverdo C" first="Claude" last="Loverdo">Claude Loverdo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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